Gel formulations containing Sumbawa's horse milk with carbomer as gelling agent

Dian Ermawati, Uswatun Chasanah, Herika Juli Andani, Khalda Nisrina


Abstract


Peptides from Sumbawa horse milk are active as antibacterial and antioxidant. Horse milk has a higher content of vitamin C than cow or goat's milk, and cream products that contain milk can overcome dry skin. The Gel is one of the topical dosage forms suitable for acne medications and oily skin types. The aim of this study was to determine the effect of variations in horse milk content formulated in gel preparations with carbomer 1% base as gelling agents on physical characteristics (organoleptic, viscosity, pH) and on antibacterial activity in Propionibacterium acnes. In this study, preparations were made with six different formulas on horse milk content, namely FI (2.5%), FII (5%), and FIII (10%), FIV (15%), FV (20%), and FVI (25%) with 1% carbomer base on each formula and well method was used for antibacterial test. The results of organoleptic testing, it was found that in all soft textured preparations, concentrated white and smelled typical of horse milk. The results showed that in viscosity, there was no significant difference. The pH of the gel preparation for each formula, indicating that there is a significant difference in pH in the preparation. There is an effect of increasing horse milk levels on pH on gel preparations. In this study showed that from 2.5% to 25% horse milk concentration did not have an inhibitory zone, which means that at each level there was no evidence of antibacterial activity in the P. acnes. Sumbawa horse milk could be formulated in gel form with 1% carbomer base starting from horse milk concentration 2.5% to 20%. Starting from low to highest levels, it still shows good gel characteristics but there is no inhibitory activity against the P. acnes.


Keywords


Formulation; Gel; Carbomer; Horse Milk



DOI: https://doi.org/10.22219/farmasains.v4i1.6892

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Creative Commons License

Creative Commons Attribution 4.0 International License.