Farmasains : Jurnal Farmasi dan Ilmu Kesehatan

Evaluation of the mucolytic activity of ethanol extract of Temu Ireng (Curcuma aeruginosa Roxb.)

2024-08-13T15:13:33+07:00

Curcuma aeruginosa Roxb., known as Temu Ireng, is a species within the Zingiberaceae family that has been empirically noted for its potential as a cough remedy. Temu Ireng contains alkaloids, flavonoids, and saponins, which play crucial roles in mucus liquefaction. This study aims to investigate the mucolytic activity of the ethanol extract of Curcuma aeruginosa Roxb. In this study, we used an experimental method. The extract was obtained via maceration and analyzed in vitro for its ability to reduce the viscosity of bovine intestinal mucus using a digital viscometer. Bovine intestinal mucus was utilized due to its compositional similarity to human mucus. Test sample concentrations of the Temu Ireng extract were 1.0%, 1.5%, and 2.0%, with acetylcysteine serving as the positive control. Mucolytic activity was indicated by a decrease in mucus solution viscosity. The data were analyzed using one-way ANOVA. The results demonstrated a decrease in mucus viscosity for the Temu Ireng extract test solutions, with statistical analysis indicating a significant difference between the negative control and both the positive control and the Temu Ireng extract samples at concentrations of 1.5% and 2.0%, with p-values of 0.032 and 0.030 respectively (p<0.05). The study concludes that the ethanol extract of Curcuma aeruginosa Roxb. exhibits mucolytic activity at concentrations of 1.0%, 1.5%, and 2.0%.

Formulation and test of physical properties of eyeshadow cream with natural dyes of Kasumba turate flower extract (Carthamus tinctorius L.)

2024-05-10T15:47:04+07:00

Safflower (Carthamus tinctorius L.) contains two natural pigments,, namely yellow carthamin and orange-red carthamin dye which are used as natural dyes. The research aimed to see whether safflower extract could be used as a natural coloring in eyeshadow cream and the physical properties of eyeshadow cream. The 70% ethanol extract of safflower was formulated into lip cream preparations, with varying concentrations of 0% (K-), 1% (F1), 2% (F2), and 3% (F3). Testing the physical properties of the preparation, namely the organoleptic test, homogeneity test, pH test, type of cream test, spread test, spreadability test, viscosity test, and hedonic test. The formulation of the lip cream of safflower extract showed a distinctive smell of orange essence, yellow to brownish yellow color, semi-solid form, homogeneous preparation until the 28th day, easy to apply, had a pH (4.5-7.0), type cream O/W, has a viscosity of 10,000-20,000 cPs and spreadability of 5-7 cm. This study concludes that Safflower extract can be used as a natural dye in Eyeshadow cream preparations and meets the requirements of good physical properties of Eyeshadow cream preparations.

The distribution of the ABO and rhesus blood groups among diabetes mellitus patients in Zintan City, Libya

2024-10-11T11:34:19+07:00

Numerous studies have explored the potential connection between ABO blood groups and the risk of developing specific illnesses in the literature. This study aimed to examine the distribution of ABO blood and rhesus (Rh) groups among patients with diabetes mellitus (DM) at the Endocrinology and Diabetes Center in Al-Zintan City, Libya. This cross-sectional study took place from October to December 2022, involving 144 blood samples (99 from diabetic patients and 45 from non-diabetic individuals aged 15 to 85 years). Ethical approval and informed consent were obtained from the Endocrinology and Diabetes Center in Al-Zintan, where all laboratory work and statistical analysis using SPSS were conducted. Of the diabetic patients, 46% were male and 53% were female. The test results showed no association between ABO and Rh blood groups in individuals with diabetes mellitus. Among diabetics, the O blood group was most prevalent at 49%, followed by A (34%), B (11%), and AB (5%). Rh+ was more common (n=88) than Rh- (n=11), with no significant difference (p=0.733). Gender distribution also showed no significant difference (p>0.05). The O blood group was more common in females (55.10%) than males (44.90%), and the B blood group was found more often in females (72.73%) than in males (27.27%). This research shows no significant relationship between ABO and Rh blood types and diabetes mellitus occurrence among patients at the endocrinology and diabetes center in Al-Zintan City. Blood group variations do not influence diabetes prevalence or characteristics in this population.

The relationship between level of knowledge and medication adherence in hypertensive patients at Pal Tiga Pontianak Health Center

2024-08-13T15:24:33+07:00

Patient non-adherence to medication use is one of the barriers to successful treatment of hypertension. One of the factors that can affect adherence is knowledge. This study aims to analyze the relationship between knowledge level and medication adherence in outpatient hypertensive patients at the Pal Tiga Pontianak Health Center. This research method is an analytic observational study using a cross-sectional research design. This research was conducted during January-February 2024 with a total of 112 respondents. Data collection used the Hypertension Knowledge-Level Scale (HK-LS) and Adherence to Refill and Medication Scale (ARMS) questionnaire. The results showed that the characteristics of outpatients at Pal Tiga Pontianak Health Center tended to be female (61.6%), aged >45 years (93.8%), not working (72.3%), minimum education level of high school (58.9%), have a high level of knowledge (76.8%) and high level of adherence (56.3%). Chi-square analysis showed no significant relationship between gender (p=0.243), age (p=0.465), and occupation (p=1.000). Meanwhile, there was a significant relationship between the education level (0.012) and the adherence level with the use of antihypertensive drugs. The relationship obtained between the level of knowledge and adherence of hypertensive patients is p=0.044 (p<0.05). The conclusion of this study is that there is a significant relationship between the knowledge level and the adherence level of hypertensive patients at the Pal Tiga Pontianak Health Center

Antidiabetic activity test of infusion combination rosella flower (Hibiscus sabdariffa L.) and cinnamon bark (Cinnamomum burmannii (Nees & T. Nees) Blume) in male mice (Mus musculus) induced by alloxan

2024-10-11T11:51:48+07:00

Diabetes Mellitus (DM) is a disorder of carbohydrate, lipid and protein metabolism which is characterized by increased blood glucose levels. The existence of DM as a public health problem is increasing globally. This experimental research was carried out to determine the activity of a combination of rosella flower infusion and cinnamon bark on blood glucose levels in male mice that had been induced by alloxan. After ensuring that the blood glucose level of the mice was >175 mg/dl, 4 groups were tested, namely test group 1 was given a single rosella flower infusion, test group 2 was given a single cinnamon bark infusion, test group 3 was given a combination of rosella flower infusion and stem bark cinnamon, and the control group were given aqua destillata. Based on the results of the Kruskal-Wallis non-parametric statistical test, it shows a value of p = 0.009 (p £ 0,05), which means there is a difference in the reduction in blood glucose levels between the test groups. Then, to determine the greatest decrease in glucose levels, a Post Hoc test was carried out and the highest mean rank value was obtained (13.00) in the infusion group of the combination of rosella flowers and cinnamon bark, followed by the cinnamon bark infusion group (5.80), and the rosella flower infusion group (5.20).