The Effect Of Red Dragon Fruit Peel Extract Gel On Rattus Norvegicus Strain Wistar Of Grade Iia Burns Surface Area

Abstract

Background: Burns are injuries to body tissues by electric shocks, chemicals, or hot objects. Peel of red dragon fruit contains anti-inflammatory and antibacterial compounds, so it can accelerate the healing of grade IIA burns. Purpose: To prove the effect of red dragon fruit peel extract gel on the surface area of grade IIA burns of Rattus norvegicus strain wistar. Methods: Experimental with post test only control group design. The samples were divided into 5 groups, 1 (Base Gel), 2 (Burnazin plus cream), 3 (Red dragon fruit peel extract gel 10%), 4 (Red dragon fruit peel extract gel 15%), 5 (Red dragon fruit peel extract gel 20%),. The rats' backs were attached by a metal that has been heated in water at 100 ° C for 3 minutes without pressing for 10 seconds. The treatment was carried out for 14 days, then the wound area was measured on the 4th, 7th, and 14th days. The data were analyzed using MANOVA test, Post-hoc Bonferroni and Pearson Correlation. Results: The results of the MANOVA test showed significant differences in the area of the wound on the 14th day. Post-hoc test showed a significant difference occurred in group 5. Pearson Correlation test showed that the effect of red dragon fruit peel extract gel on day 14 was 0.820 which was included in the strong category. Conclusion: There is an effect of red dragon fruit peel extract gel on the area of second degree burns of Rattus norvegicus strain wistar.