The Potential Of Apples In Preventing Tracheal Goblet Cell Hyperplasia
DOI:
https://doi.org/10.22219/apisio.Vol1.AM2.42240Abstract
Background: Goblet cells have a role in producing mucus response to irritant gases, inflammatory mediators, ROS, and changes the biophysical environment. Goblet cell hyperplasia found in e-cigarette exposure is characterized by increased mucus secretion in respiratory tract and tobacco exposure also causes oxidative stress, increases inflammation mucosa. The compounds in apples such as phloretin was found to inhibit goblet cell hyperplasia. Method: Literature review 34 journals and 4 textbook. The journal from Google, NCBI and Pubmed, and research materials into new information related to the research objectives. Result: Factors that cause goblet cell hyperplasia include exposure to conventional cigarettes, e-cigarettes, diesel exhaust, and pathological conditions such as asthma and COPD. The liquid content (PG / VG) in e-cigarettes was found to have an effect on increasing mucin production (MUC5AC). The content of polyphenol compounds in apples such as quercetin and phloretin can prevent tracheal goblet cell hyperplasia and mucin production. Conclusion: Quercetin and phloretin in apples can prevent tracheal goblet cell hyperplasia and mucin production.
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