RESPONS IMUN DAN PEMERIKSAAN SEROLOGI PADA TUBERKULOSIS

Authors

  • Diah Hermayanti

DOI:

https://doi.org/10.22219/sm.v7i1.1086

Abstract

Tuberculosis merupakan penyakit yang biasanya menyerang paru-paru. Inhalasi droplet yang mengandung sedikit bakteri Mycobacterium tuberculosis ditelan oleh makrofag alveolar. Makrofag merupakan sel target utama, namun kemudian setelah teraktifasi, akan membunuh bakteri ini dan berpartisipasi dalam respons protektif sel tipe-1 T helper  dan respons Th2 untuk bakteria target ekstraseluler yang disebut imunitas humoral.

                Pemeriksaan serologi diperlukan pada  kasus dimana pemeriksaan penunjang rutin sulit untuk menegakkan diagnose tuberculosis. Pemeriksaan tersebut antara lain menggunakan reagen dari antigen seperti antigen 5 (antigen 38 Kd), antigen kompleks 85, Early secreted antigen target (ESAT-6), antigen culture filtrate protein (CFP)-10, antigen Malate Synthase (MS) dan MPT-51. Namun demikian tidak ada pemeriksaan imunologi tunggal yang mempunyai sensisitivitas 100%, diperlukan kombinasi beberapa pemeriksaan untuk meningkatkan sensitivitasnya.

Kata kunci : tuberkulosis, respons protektif, pemeriksaan serologi

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Published

2012-10-11

Issue

Vol. 7 No. 1 (2011): Januari 2011

Section

Article

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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.