The Effect Of Moringa Leaf (Moringa Oleifera Lam) And Vitamin C Combination Extract In Improving Anemia Indicators Deficiency Of White Rice Iron Male Diet Low Rice Iron

Authors

  • Diah Hermayanti
  • Hawin Nurdiana Universitas MUhammadiyah Malang
  • Wahyu Setiawan
  • Refa Maulana Azhar

DOI:

https://doi.org/10.22219/sm.Vol16.SMUMM2.15029

Keywords:

iron deficiency anemia, moringa leaf extract, vitamin C, hemoglobin, serum iron.

Abstract

Iron deficiency anemia is still a major health problem in developing countries. Therapy with iron preparations often causes undesirable side effects. Moringa leaf extract which is rich in iron can be used as an alternative therapy in iron deficiency, and combination with vitamin C can increase the effectiveness of iron absorption in the gastrointestinal tract. determine the effect of the combination of Moringa oleifera lam. Extract and vitamin C on the indicator of iron deficiency anemia in white rats (Rattus Novergicus Strain Wistar) who were given a diet low in iron aking rice. True experimental research design using post test only control group design. The object of this study was male white rats (Rattus novergicus Strain wistar) induced by a low-iron rice diet. The study was divided into negative control group, positive control group, the treatment group with Moringa leaf extract dose of 400 mg / kg body weight, 800 mg / kg body weight, 1,600 mg / kg body weight. The treatment group was given vitamin C in a dose of 40 mg. Results and Discussion One wayAnova test, hemoglobin sig. 0,000 (p <0.05), MCV sig 0.27 (p> 0.05), MCH sig 0.16 (p> 0.05), serum iron sig. 0,000 (p <0.05), transferrin saturation sig. 0.006 (p <0.05), and TIBC sig 0.68 (p> 0.05). Pearson correlation for hemoglobin 0.746 (sig.0,000), and linear regression with R2 0.557 (sig.0,000); for serum iron 0.742 (sig.0,000) with R2 0.551 (sig.0,000). There was an increase in hemoglobin and serum iron levels in the treatment group.

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References

Anisa N, Wahyuni S, Rahayu S, et all, 2019, Effect of Moringa Leaves and Vitamin C Capsule Combination in Increasing Gemoglobin Levels of Young Women With Anemia, Proceedings of International Conference on Applied Science and Health No 4, https://publications.inschool.id/index.php/icash/article/viewFile/398/311

Adamson JW. 2015. Iron Deficiency and Other HypoproliferativeAnemias. In: Kasper DL, Hauser SL, Jameson JL, et al (eds). Harrison’s Principles of Internal Medicine. 19 eds. McGraw-Hill Education. USA. pp.625 – 630

Alabsi S, DeVore K, Willson R. 2010. Guidelines for The Use of Ferrous Sulfate (Fer-In-Sol), https://www.unitypoint.org/blankchildrens/filesimages/

Calistania C, Mulansari NA. 2014. 2014. AnemiaDefisiensiBesi. In: Tanto C, Liwang F, et al (eds). Kapital SelektaKedokteran. 4thedn. Media Aesculapius: Jakarta. pp. 653 – 655.

Devkota BP, 2014, Iron Binding Capacity, Medscape, http://emedicine.medscape.com/article/2085726-overview

Dossou I, Diouf A, gueye AL, Guiro AT, 2011, Impact of Daily Compsumtion of Moringa oleifera) dry leaf powder on iron status of Senegalese Lactating Women, AJFAND, Vol. 11 No.4, https://tspace.library.utoronto.ca/bitstream/1807/55729/1/nd11044.pdf

Jimenez K, Dabsch SK, Gasche C, 2015, Gastroenterol Hepatol 11(4):241-250, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836595/

Gallaler DD, 2017, Iron bioavalibility from Moringa oleifera leaves is very low, FASEP Juornal, abstract number : 786.13 https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.786.13

Goddard AF, James MW, Mclntyre AS, Scott BB, 2011, Guidelines for the management of iron deficiency anaemia, Gut 60 :1309-1316, http://www.spg.pt/wp-content/uploads/2015/11/2011-bsg_ida.pdf

Gophalan C, Sastri BVR, and Balasubramanian SC. 2010. Nutritive value of Indian foods.In: Trees for Life. Moringa. Trees for Life: Wichita

Goodnough LT, Nemeth E, 2014, Iron Deficiency and Related Disorders, Wintrobe’s Clinical Hematology 13 th eds, Greer JP Ed, Lippincott Williams & Wilkins, Philadelphia, pp.617-42

Harper JL, 2016, Iron Deficiency Anemia Treatment & Management, Medscape, http://emedicine.medscape.com/article/202333-treatment

Kathryn A.2011. The Nutrient Content of Moringa Oleifera Leaves. Educational Concerns for Hunger Organization.

Miniero R, Talarico V, Galati MC, et al, 2018, Iron Deficiency dan Iron Deficiency Anemia in Children, Intechopen, https://www.intechopen.com/books/iron-deficiency-anemia/iron-deficiency-and-iron-deficiency-anemia-in-children

Mun’im A, Puteri MU, Sari SP, et al, 2016, Anti Anemia Effect of Standarized Extract of Moringa oleifera Lamk Leaves on Aniline induced Rats, Pharmacognosy Journal, Vol.8, pp.255-258, https://www.researchgate.net/publication/303975796_Anti-Anemia_Effect_of_Standardized_Extract_of_Moringa_Oleifera_Lamk_Leaves_on_Aniline_Induced_Rats

Napitupulu R, Wisaksono S, Efizal (eds). 2008. TaksonomiKoleksiTanamanObatCiteureup. Badan PengawasObat dan Makanan Indonesia: Jakarta. pp. 58

Nazar H &Usmaghani K . 2015. An Integrated Approach To Iron DeficienyAnemia. Indian Journal of Traditional Knowledge. Vol 1. pp. 36 – 41

Osman HM, Shayoub ME, Babiker EM, et al, 2012, Effect of Ethanolic Leaf Extractnof

Moringa Oleifera on Aluminium-induced Anemia in White albino Rats, Jordan Journal of Biological Science, Vo.5, pp. 255-260, http://jjbs.hu.edu.jo/files/v5n4/Paper%20Number%205m.pdf

Parmar BJ, Jwal Doctor, Ruhi, et al.2017. Iron Definition : Beyond Anemia. Academic

Journal of Pediatrics and Neonatology. Vol 2, https://pdfs.semanticscholar.org/8660/d1f401d9c7dd1b8c7e65f11b7e0fd4ff9545.pdf

Riskesdas, 2013, Riset Kesehatan Dasar, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI Tahun 2013, http://www.depkes.go.id/resources/download/general/Hasil%20Riskesdas%202013.pdf

Suzana D, Suyatna FD, Azizahwati, Andrajati R, et al, 2017, Effect of Moringa oleivera leaves extract against hematology and blood biochemical value of patient with iron deficiency anemia, J Young Pharm, 2017; 9(1) Suppl:s79-s84, https://www.jyoungpharm.org/sites/default/files/10.5530jyp.2017.1s.20.pdf

Teucher B, Olivares M, Cori H, 2004, Enhancer of Iron Absorption : Ascorbic Acid and

Other Organic Acids, Int J VitamNutr Res, Vol 74 (6) : 403-19, https://www.ncbi.nlm.nih.gov/pubmed/15743017

Vicente JFH, Conesa DP, Rincon F, et al, 2008, Does ascorbic acid supplementation Affect Iron Bioavailability in Rats Fed Micronized Dispersible Ferric Pyrophosphate Fotified Fruit Juice ?, European Jornal of Nutrition, abstract, Vol. 47 :470, https://link.springer.com/article/10.1007%2Fs00394-008-0750-7

Waldvogel AS, Waeber G, Gassner C, et al, 2014, Physiology of Iron Metabolism, Transfus Med Hemother: 41:213-221, https://www.karger.com/Article/Fulltext/362888

WHO, 2015, The Global Prevalence of Anemia in 2011, WHO Document Production Services, Geneva, Switzerland

Yulianti H, Hadju V, Elma Alasiry. 2016. Pengaruh Ekstrak Daun Kelor Terhadap Peningkatan Kadar Hemoglobin Pada Remaja Putri di SMU Muhammadiyah Kupang. JST Kesehatan. Vol 6. pp. 399 – 404, http://pasca.unhas.ac.id/jurnal/files/ed8261950756a76bd88cb394117dc80a.pdf

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Published

2020-12-29