Body Mass Index and HbA1c Are Associated with Renal and Hepatic Function


  • Yoga Mulia Pratama Department of Internal Medicine, Faculty of Medicine, Jenderal Soedirman University
  • Falah Faniyah Department of Pediatrics, Faculty of Medicine, Jenderal Soedirman University
  • Imam Nafiyana Saputra Department of Obstetrics and Gynecology, Faculty of Medicine, Jenderal Soedirman University



Diabetes, hypertension, body mass index, HbA1c


Hypertension and diabetes may have implications for damage to other organs such as the kidneys and liver which are evaluated by serum creatinine and ALT, respectively. This study aims to delineate the association between body mass index and hbA1c with renal and hepatic function, respectively. This is a cross-sectional study involving 32 subjects. The research subjects consisted of diabetics and hypertension who were registered in the Muhammadiyah Primary Health Care, Kebanaran, Purwokerto. It was found that in diabetics, there were significant results between serum creatinine and HbA1c values (p <0.01, r = 0.855). Systolic blood pressure was correlated with body mass index (BMI) (p <0.01, r = 0.649). In patients with hypertension, serum creatinine was correlated with the length of time a person has hypertension (p <0.01, r = 0.475). Meanwhile, the ALT value was correlated with body mass index (p <0.05, r = 0.422) and waist circumference (p <0.001, r = 0.528). We found that a decreased HbA1c levels significantly reduces serum creatinine levels so it may also reduce kidney damage. A decrease in the value of BMI and waist circumference significantly reduces ALT enzyme levels which may have the potential for reducing liver damage.


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Author Biographies

Yoga Mulia Pratama, Department of Internal Medicine, Faculty of Medicine, Jenderal Soedirman University

Department of Internal Medicine, Faculty of Medicine, Jenderal Soedirman University

Falah Faniyah, Department of Pediatrics, Faculty of Medicine, Jenderal Soedirman University

Department of Pediatrics, Faculty of Medicine, Jenderal Soedirman University

Imam Nafiyana Saputra, Department of Obstetrics and Gynecology, Faculty of Medicine, Jenderal Soedirman University

Department of Obstetrics and Gynecology, Faculty of Medicine, Jenderal Soedirman University


Betz, H. H., Eisenmann, J. C., Laurson, K. R., DuBose, K. D., Reeves, M. J., Carlson, J. J., & Pfeiffer, K. A. 2018. Physical Activity, BMI, and Blood Pressure in US Youth: NHANES 2003-2006. Pediatric exercise science, 30: 418–425.

Bilal, M., Tariq, A., Khan, S., Quratulain, Tariq, A., Shahid, M. F., Khan, M. W., Shah, A. R., & Naveed, A. K. 2011. Influence of gender, BMI, and ethnicity on serum ALT levels of healthy students of a medical school. Journal of Ayub Medical College, Abbottabad : JAMC, 23: 70–72.

Colombo, M., McGurnaghan, S. J., Blackbourn, L. A. K., Dalton, R. N., Dunger, D., Bell, S., Petrie, J. R., Green, F., MacRury, S., McKnight, J. A., Chalmers, J., Collier, A., McKeigue, P. M., & Colhoun, H. M. 2020. Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes. Diabetologia, 63: 788–798.

Deacon, C. F. 2019. Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes . Frontiers in Endocrinology .

Fan, R., Wang, J., & Du, J. 2018. Association between body mass index and fatty liver risk: A dose-response analysis. Scientific reports, 8: 15273.

Farasat, T., Sharif, S., Naz, S., & Fazal, S. 2015. Significant association of serum creatinine with HbA1C in impaired glucose tolerant Pakistani subjects. Pakistan journal of medical sciences, 31: 991–994.

Hamasaki, H., & Morimitsu, S. 2020. Association of Glucagon With Obesity, Glycemic Control and Renal Function in Adults With Type 2 Diabetes Mellitus. Canadian journal of diabetes.

Ito, M., Matsue, Y., & Minamino, T. 2020, September. Worsening renal function during intensive blood pressure control: another example of not prognostically relevant creatinine rise? European journal of heart failure. England.

Langholz, P. L., Wilsgaard, T., Njølstad, I., Jorde, R., & Hopstock, L. A. 2021. Trends in known and undiagnosed diabetes, HbA1c levels, cardiometabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys: the population-based Tromsø Study 1994-2016. BMJ open, 11: e041846.

Mangus, R. S., Fridell, J. A., Kubal, C. A., Davis, J. P., & Tector, A. J. 2015. Elevated alanine aminotransferase (ALT) in the deceased donor: impact on early post-transplant liver allograft function. Liver international : official journal of the International Association for the Study of the Liver, 35: 524–531.

Menteri Kesehatan RI. 2015. Peraturan Menteri Kesehatan RI Nomor 71 Tahun 2015 Tentang Penanggulangan Penyakit Tidak Menular, 1–15.

Menteri Kesehatan RI. 2018. Indonesia Health Profile 2017. Jakarta, Indonesia: Menteri Kesehatan RI.

Mills, K. T., Stefanescu, A., & He, J. 2020. The global epidemiology of hypertension. Nature Reviews Nephrology, 16: 223–237.

Nistala, R., & Savin, V. 2017. Diabetes, hypertension, and chronic kidney disease progression: role of DPP4. American journal of physiology. Renal physiology, 312: F661–F670.

Ravindrarajah, R., Reeves, D., Howarth, E., Meacock, R., Soiland-Reyes, C., Cotterill, S., Whittaker, W., Heller, S., Sutton, M., Bower, P., & Kontopantelis, E. 2020. Epidemiology and determinants of non-diabetic hyperglycaemia and its conversion to type 2 diabetes mellitus, 2000-2015: cohort population study using UK electronic health records. BMJ open, 10: e040201.

Schnell, O., Crocker, J. B., & Weng, J. 2017. Impact of HbA1c Testing at Point of Care on Diabetes Management. Journal of diabetes science and technology, 11: 611–617.

Song, B. M., Kim, H. C., Kim, D. J., Ahn, S. V., Kim, K. M., Lee, J.-M., Koh, S.-B., & Suh, I. 2018. Aminotransferase levels, body mass index, and the risk of diabetes: a prospective cohort study. Annals of epidemiology, 28: 675-680.e6.

Sung, K.-C., Ryu, S., Lee, J.-Y., Lee, S. H., Cheong, E., Hyun, Y.-Y., Lee, K.-B., Kim, H., & Byrne, C. D. 2016. Urine Albumin/Creatinine Ratio Below 30 mg/g is a Predictor of Incident Hypertension and Cardiovascular Mortality. Journal of the American Heart Association, 5.

Teshome, G., Ambachew, S., Fasil, A., & Abebe, M. 2019. Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study. EJIFCC, 30: 303–316.

Viazzi, F., Russo, E., Mirijello, A., Fioretto, P., Giorda, C., Ceriello, A., Copetti, M., Russo, G. T., Di Bartolo, P., Manicardi, V., Leoncini, G., De Cosmo, S., & Pontremoli, R. 2020. Long-term blood pressure variability, incidence of hypertension and changes in renal function in type 2 diabetes. Journal of hypertension, 38: 2279–2286.

Vrettos, I., Voukelatou, P., Pappa, E., Beletsioti, C., Papadopoulos, A., & Niakas, D. 2020. Increased Body Mass Index and Hypertension: An Unbreakable Bond. International journal of preventive medicine, 11: 155.

Wang, L., Guo, J., & Lu, J. 2016. Risk factor compositions of nonalcoholic fatty liver disease change with body mass index in males and females. Oncotarget, 7: 35632–35642.

Willey, J. Z., Moon, Y. P., Husain, S. A., Elkind, M. S. V, Sacco, R. L., Wolf, M., Cheung, K., Wright, C. B., & Mohan, S. 2020. Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: The Northern Manhattan Study. PloS one, 15: e0226509.

Yamout, H., & Bakris, G. L. 2018, January. Consequences of Overinterpreting Serum Creatinine Increases when Achieving BP Reduction: Balancing Risks and Benefits of BP Reduction in Hypertension. Clinical journal of the American Society of Nephrology : CJASN.

Zheng, T., Chen, T., Liu, Y., Gao, Y., & Tian, H. 2015. Increased plasma DPP4 activity predicts new-onset hypertension in Chinese over a 4-year period: possible associations with inflammation and oxidative stress. Journal of human hypertension, 29: 424–429.

Zhou, W., Shi, Y., Li, Y.-Q., Ping, Z., Wang, C., Liu, X., Lu, J., Mao, Z.-X., Zhao, J., Yin, L., Zhang, D., Tian, Z., Zhang, L., & Li, L. 2018. Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies. Journal of human hypertension, 32: 321–333.

Zubair, M., Malik, A., & Ahmad, J. 2019. Correlation of HbA1c and S. creatinine along with microbiological profiling of infected ulcers; cases of diabetic patients. Diabetes & metabolic syndrome, 13: 30–34.