Comparison Of The Effectiveness And Safety Of Anemia Epoetin Alfa With Epoetin Beta Inhemodialysis Routine Patients At Haji Rsu Surabaya

Gunawan  Widodo; Anita  Purnamayanti; Hesti Trisnianti Burhan Burhan; Burhan

doi:10.22219/sm.Vol17.SMUMM2.18228

Authors

Gunawan
Anita
Hesti
Burhan

DOI:

https://doi.org/10.22219/sm.Vol17.SMUMM2.18228

Abstract

Chronic Kidney Disease (CKD) is a disorder of the structure / function of kidney> 3 months marked by pathology and renal damage marker and impairment Glomerular filtration rate (GFR). Erythropoietin is agrowth factor hematopoietic that plays a role in the formation of red blood cells 5. Research conducted by Henry et al, on the pharmacokinetics of epoetinalfa showed the results that epoetinalfa has the effectiveness of increasing Hb concentration within 2-6 weeks with a half-life of 4-5 hours. Epoetin therapy was given with indications of Hb< 10 g/dL, no absolute iron deficiency anemia Transferrin Saturation > 20%, Serum Ferritin and no severe infection. At RSU HAJI, the insurance company bears the cost of administering epoetinalfa at a dose of 3000 IU and epoetin beta at a dose of 2000 IU to anemic patients undergoing HD, with several written conditions, namely the administration of epoetinalfa/beta given twice a week ,Hb< 10 g/dL, TSAT > 20%, FS > 200 ng/L, and no severe infection. The research subjects were divided into 2 groups, namely a group of patients receiving treatment for epoetin alpha 3000 IU/2x a week and a group of patients receiving epoetin beta anemia therapy 2000 IU/2x a week, with the direction of data collection being a combination of retrospective methods. Based on the results of research that has been conducted on the comparison of the effectiveness and safety of anemia therapy with epoetinalfa and epoetin beta in routine hemodialysis patients at RSU HAJI Surabaya.

Downloads

Download data is not yet available.

Author Biography

Gunawan

Rsu Haji Surabaya jl Manyar Kertoadi

References

Angela Yee-Moon Wang, Tadao Akizawa, Sunita Bavanandan, Takayuki Hamano, Adrian Liew, Kuo-Cheng Lu, Dusit

Lumlertgul, Kook-Hwan Oh, Ming-Hui Zhao, Samuel Ka-Shun Fung, Yoshitsugu Obi, Keiichi Sumida, Lina Hui Lin Choong, Bak Leong Goh, Chuan-Ming Hao, You, Y. T. and M. F. (2019). 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update Implementation: Asia Summit Conference Report. Kidney https://doi.org/10.1016/j.ekir.2019.09.007

Ali Reza Khoshbin, Fahimeh Mohamadabadi , Fatemeh Vafaeian , Adel Babania , Saeideh Akbarian , Reza Khandozi ,Mohamad Ali Sadrebazaz , Ehsan Hatami , Hamid Reza Joshaghani. The effect of radiotherapy and chemotherapy onosmotic fragility of red blood cells and plasmalevels of malondialdehyde in patients with breast cancer. Reports of Practical Oncology & Radiotherapy. http://dx.doi.org/10.1016/j.rpor.2014.11.002

A.M. Thompson, K. Farmer, E.K. Rowe, S.P. Hayley (2020), Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease, Molecular and Cellular Neuroscience, doi: https://doi.org/10.1016/j.mcn.2020.103554

Abdulrahman Alwhaibi, Sary Alsanea, Ziyad Alrabiah, Fars K. Alanazi, Badraddin M. Al-Hadiya, Hisham S. Abou-Auda (2021). Pharmacokinetic Profile of Sildenafil Citrate in Healthy Middle Eastern Males: Comparison with Other Ethnicities. https://doi.org/10.1016/j.jsps.2021.11.011

Coyne, D. W., Roger, S. D., Shin, S. K., Kim, S. G., Cadena, A. A., Moustafa, M. A., … Yu, K. H. P. (2021). Roxadustat for CKD-related Anemia in Non-dialysis Patients. Kidney International Reports, 6(3), 624–635. doi: https://doi.org/10.1016/j.ekir.2020.11.034

Dennis Stalker, PhD; Susan Reid, MEd, PMP; Atulkumar Ramaiya, PhD; Wayne A. Wisemandle, MA; and Nancy E. Martin, PharmD, MD (2016). Pharmacokinetic and Pharmacodynamic Equivalence of Epoetin Hospira and Epogen After Single Subcutaneous Doses to Healthy Male Subjects. doi: https://doi.org/10.1016/j.clinthera.2016.06.010

Elisa Piva, MDa, Carlo Brugnara, MDb, Federica Spolaore, MDa, Mario Plebani, MDa,(2015), Clinical Utility of Reticulocyte Parameters, Clinics in Laboratory Medicine, doi: https://doi.org/10.1016/j.cll.2014.10.004

George Nasr, Diana Glovaci, Sonia Samtani, Jimmy Kwon, Wei Zhou, Pranav Patel, Dawn Lombardo, University of California,Irvine, Health System, Orange, CA, USA9 (2020).Assessing The Necessity Of Non-Invasive Stress Testing For Cardiac Clearance Inckd Patients On Hd Undergoing Renal Transplant Evaluation, Journal of the American College of Cardiology, doi: https://doi.org/10.1016/S0735-1097(20)31781-2

Haine, L., Yegen, C. H., Marchant, D., Richalet, J. P., Boncoeur, E., & Voituron, N. (2021). Cytoprotective effects of erythropoietin: What about the lung? Biomedicine and Pharmacotherapy, 139, 111547. doi: https://doi.org/10.1016/j.biopha.2021.111547

Hiddo J.L. Heerspink1, 2, 16, David Cherney3, 16, Douwe Postmus4, Bergur V. Stefa´nsson5, Glenn M. Chertow6, Jamie P. Dwyer7, Tom Greene8, Mikhail Kosiborod2, 9, Anna Maria Langkilde5, John J.V. McMurray10, Ricardo Correa-Rotter11, Peter Rossing12, 13, C., 15; on behalf of the DAPA-CKD Trial Committees and Investigators. (2021). A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function. Kidney International, 2. doi: https://doi.org/10.1016/j.kint.2021.09.005

Ines Silva, Carolina Alípio , Rui Pinto, Vanessa Mateus (2021), Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: A systematic review, Biomedicine & Pharmacotherapy, doi: https://doi.org/10.1016/j.biopha.2021.111558

International Reports, 4(11), 1523–1537. doi: https://doi.org/10.1016/j.ekir.2019.09.007

Jay B. Wish, Stefan D. Anker, Javed Butler, Aleix Cases, A. G. S. and, & Macdougall, I. C. (2021). Iron Deficiency in CKD Without Concomitant Anemia. Kidney International Reports, 6(11), 2752–2762. https://doi.org/10.1016/j.ekir.2021.07.032

Lanpeng Ji , Peng Liu , Stephan Robert (2019). Tail asymptotic behavior of the supremum of a class ofchi-square processes. Statistics and Probability Letters. https://doi.org/10.1016/j.spl.2019.07.001

Laura Arelí Sánchez-Carrillo MD , Juan Manuel Rodríguez-López MD , Dionisio Ángel Galarza-Delgado MD , Laura Baena-Trejo MD , Magaly Padilla-Orozco MD , Lidia Mendoza-Flores MD , Adrián Camacho-Ortiz MD (2016). Enhancement of hand hygiene compliance among health care workers from a hemodialysis unit using video-monitoring feedback. American Journal of Infection Control. doi: http://dx.doi.org/10.1016/j.ajic.2016.01.04

M. Basora, M.J. Colomina , M. Tio , L. Mora , G. Sánchez-Etayo , F. Salazar ,E. Ciércoles , M. Panos, E. Guerrero y, R. Berge (2015) , Optimización de la hemoglobina preoperatoria en cirugía ortopédica mayor utilizando hierro intravenoso con o sin eritropoyetina. Estudio epidemiológico, Revista Española de Anestesiología y Reanimación, doi: https://doi.org/10.1016/j.redar.2014.07.011

Manisha Jain , Prantar Chakrabarti , Tuphan Kanti Dolai , Pramit Ghosh , Prakas Kumar Mandal , Shuvra Neel Baul , Rajib De (2021), Comparison of efficacy and safety of thalidomide vs hydroxyurea in patients with Hb E-β thalassemia - a pilot study from a tertiary care Centre of India, Blood Cells, Molecules and Diseases, doi: https://doi.org/10.1016/j.bcmd.2021.102544

Mengyao Tang, Jonathan A. Batty, Chiayu Lin, Xiaohong Fan, Kevin E. Chan, Sahir Kalim. Pulmonary Hypertension, Mortality, and Cardiovascular Disease in CKD and ESRD Patients: A Systematic Review and Meta-analysis. American Journal of Kidney Diseases. doi: https://doi.org/10.1053/j.ajkd.2017.11.018

P. Fenaux, V. Santini, M. Aloe Spiriti3, Giagounidis, R. Schlag, Radinoff6, L. Gercheva-Kyuchukova, Anagnostopoulos,. Oliva, Symeonidis, M. Hunault Berger, K. Götze. Potamianou, H. Haralampiev, R. Wapenaar, I. Milionis,U. Platzbecker (2017). Challenging Iwg 2006 Response Criteria: Results Of A Randomized Study Of Epoetin Alfaversus Placebo In Anemic Lower Risk Mds Patients. Leukemia Research. doi: https://doi.org/10.1016/S0145-2126(17)30149-2

Qiyan Zheng, Huisheng Yang, Luying Sun, Ruojun Wei, Xinwen Fu, Y., & Wang, Yishan Huang, Yu Ning Liu, W. J. L. (2020).

Efficacy and safety of HIF prolyl-hydroxylase inhibitor vs epoetin and darbepoetin for anemia in chronic kidney disease patients not undergoing dialysis: A network meta-analysis. Pharmacological Research, 159, 105020. doi: https://doi.org/10.1016/j.phrs.2020.105020

Rafael Bejar and David P. Steensma (2014). Recent developments in myelodysplastic syndromes. The American Society of Hematology. doi: https://doi.org/10.1182/blood-2014-04-522136

Robert Provenzano, MD, Anatole Besarab, MD, Steven Wright, MD, Lynda Szczech, MD, MSCE, K.H. Peony Yu, MD, Thomas B. Neff, MD (hc) (2016). Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving Maintenance Hemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study. Original Investigation Dialysis. doi: https://doi.org/10.1053/j.ajkd.2015.12.020

Steven Fishbane, Bruce S. Spinowitz, Wayne A. Wisemandle, Nancy E. Martin (2019). Randomized Controlled Trial of Subcutaneous Epoetin Alfa-epbx Versus Epoetin Alfa in End-Stage Kidney Disease. Kidney International Reports. https://doi.org/10.1016/j.ekir.2019.05.010

Sydney C.W.Tang, Chapter 16 - ESRD in South-East Asia, Chronic Kidney Disease in Disadvantaged Populations, doi: https://doi.org/10.1016/B978-0-12-804311-0.00016-9

Sandra Ribeiro, Luís Belo, Flávio Reis, A. S.-S. (2016). Iron therapy in chronic kidney disease: Recent changes, benefits and risks. Blood Reviews, 30(1), 65–72. doi: https://doi.org/10.1016/j.blre.2015.07.006

Zaki Morad, MBBS, FRCP (E), 1 Hui Lin Choong, MBBS, MMed (IntMed), FAMS, 2 Kriang Tungsanga, MD, 3 and Suhardjono, MD, P., & WKF. (2015). Funding Renal Replacement Therapy in Southeast Asia: Building Public-Private Partnerships in Singapore, Malaysia, Thailand, and Indonesia. American Journal of Kidney Diseases, 65(5), 799–805. doi: https://doi.org/10.1053/j.ajkd.2014.09.031