Patterns Of Drug Use In Patients With Knee Osteoarthritis At The Bina Sehat Jember Hospital


  • Firman Pratama Andraputra Universitas Jember
  • Desie Dwi Wisudanti
  • Muhammad Ali Shodikin



Osteoarthritis is a degenerative disease characterized by progressive damage to joint cartilage. The prevalence of osteoarthritis will continue to increase and continue as the population and age increase. Cases of knee osteoarthritis are more common than other types of osteoarthritis. The high prevalence of osteoarthritis will have implications for the high treatment regimen given to patients. Irrational use of drugs can lead to drug-related problems (DRPs). This study used a descriptive design. The sample in this study were knee osteoarthritis patients at the Bina Sehat Jember Hospital. The sampling technique used is purposive sampling. The data in this study used secondary data from patient medical records for the period January 2020 - April 2021. A total of 3 knee osteoarthritis patients have the potential to experience drug-related problems in the drug interaction category.


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Alwi, I., Salim, S., Hidayat, R., Kurniawan, J., & Tahapary, D. L. (2016). Panduan Praktik Klinis Penatalaksanaan di Bidang Ilmu Penyakit Dalam (1st ed.). Interna Publishing.

Bruyère, O., Honvo, G., Veronese, N., Arden, N. K., Branco, J., Bruy, O., Curtis, E. M., Al-daghri, N. M., Herrero-beaumont, G., Roth, R., Uebelhart, D., & Cooper, C. (2019). An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO). Seminars in Arthritis and Rheumatism, 49(3), 337–450.

Chincholkar, M. (2018). Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. British Journal of Anaesthesia, 120(6), 1315–1334.

Contartese, D., Tschon, M., De Mattei, M., & Fini, M. (2020). Sex specific determinants in osteoarthritis: A systematic review of preclinical studies. International Journal of Molecular Sciences, 21(10). (2021). Drug Interactions checker from

Enteshari-moghaddam, A., Azami, A., Isazadehfar, K., Mohebbi, H., & Habibzadeh, A. (2019). Efficacy of duloxetine and gabapentin in pain reduction in patients with knee osteoarthritis. Clinical Rheumatology, 38, 2873–2880.

Fathnin, F. H., Yuniastuti, A., & Kasmini, O. W. (2020). The Relation of Drug Amount, Comorbidity, Blood Pressure, and Residential Area to Drug-Related-Problems of Hypertension Patients. Public Health Perspectives Journal Fildza Huwaina Fathnin, 5(3), 2020–2178.

Garfinkel, R. J., Dilisio, M. F., & Agrawal, D. K. (2017). Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis. Orthopaedic Journal of Sports Medicine, 5(6), 1–8.

Gunawan, S. G., Setiabudy, R., Nafrialdi, & Istiaty. (2016). Farmakologi dan Terapi. Universitas Indonesia.

Gupta, R., Malhotra, A., & Malhotra, P. (2018). Study of prescription pattern of drugs used in the treatment of osteoarthritis in a tertiary care teaching hospital: an observational study. International Journal of Research in Medical Sciences, 6(7), 2380.

Katzung, B. G., Masters, S. B., & Trevor, A. J. (2014). Farmakologi Dasar & Klinik (12th ed.). EGC.

Khotib, J., Setiawan, H. U., Nurhan, A. D., Rahadiansyah, E., Ardianto, C., & Rahmadi, M. (2019). Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: Weighing clinical risk and benefit. Journal of Basic and Clinical Physiology and Pharmacology, 30(6), 1–9.

Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., Gellar, K., Harvey, W. F., Hawker, G., Herzig, E., Kwoh, C. K., Nelson, A. E., Samuels, J., Scanzello, C., White, D., … Reston, J. (2020). 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis and Rheumatology, 72(2), 220–233.

Lovell, A. R., & Ernst, M. E. (2017). Drug-Induced Hypertension: Focus on Mechanisms and Management. Current Hypertension Reports, 19:39.

Lung, B. E., Mowery, M. L., & Komatsu, D. E. E. (2021). Calcitriol. XPharm: The Comprehensive Pharmacology Reference, 1–5.

MIMS. (2019). MIMS Drug Reference (C. H. Kian (ed.); 142nd ed.). PT Medidata Indonesia.

Muslim, A. T. N., Hakim, A., & Dianti, M. R. (2018). Identification of Potential Drug Related Problems of Improper Dosage and Adverse Drug Reactions Categories in Osteoarthritis Outpatients in Rsud Jombang 2016. Journal of Islamic Pharmacy, 3(1), 23.

Nieves-Plaza, M., Castro-Santana, L. E., M. Font, Y., Mayor, A. M., & Vilá, L. M. (2013). Association of hand or knee osteoarthritis with diabetes mellitus in a population of Hispanics from Puerto Rico. Early Human Development, 83(1), 1–11.

Palazzo, C., Nguyen, C., Lefevre-Colau, M. M., Rannou, F., & Poiraudeau, S. (2016). Risk factors and burden of osteoarthritis. Annals of Physical and Rehabilitation Medicine, 59(3), 134–138.

Pharmaceutical Care Network Europe Association. (2019). Classification for Drug related problems © 2003-2017. The PCNE Classification V 9.00, 1–10.

Piva, S. R., Susko, A. M., Khoja, S. S., Josbeno, D. A., Fitzgerald, G. K., & Toledo, F. G. S. (2015). Links between osteoarthritis and diabetes: Implications for management from a physical activity perspective. Clinics in Geriatric Medicine, 31(1), 67–87.

Riskesdas. (2013). Riset Kesehatan Dasar. Badan Penelitian dan Pengembangan Kesehatan Kementerian RI.

Setiati, S., Alwi, I., Sudoyo, A. W., Simadribata, M., Setyohadi, B., & Syam, A. F. (2014). Buku Ajar Ilmu Penyakit Dalam (6th ed.). Interna Publishing.

Sherman, A. L., Ojeda-Correal, G., & Mena, J. (2012). Use of Glucosamine and Chondroitin in Persons With Osteoarthritis. PM and R, 4(5 SUPPL.), 110–116.

Soeroso, J., Harry, I., Handono, K., Rawan, B., & Riardi, P. (2014). Buku Ajar Ilmu Penyakit Dalam (6th ed.). Interna Publishing.

Suyasa, I., & Setiawan, I. (2016). The role of aging, body mass index and estrogen on symptomatic lumbar osteoarthritis in post-menopausal women. International Journal of Research in Medical Sciences, 4(5), 1325–1328.

Verma, N., Singh, A., Ali, S., & Yadav, M. (2017). Analysis of Hypertension as a Risk Factor for Osteoarthritis Knee. Hypertension Journal, 3(4), 167–170.

Wijaya, S. (2018). Osteoartritis Lutut. Cermin Dunia Kedokteran, 45(6), 424–429.

Wittenauer, R., Smith, L., & Aden, K. (2013). Priority Medicines for Europe and the World " A Public Health Approach to Innovation ". 1–31.

Xiong, J., Long, J., Chen, X., Li, Y., & Song, H. (2020). Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis. BioMed Research International, 2020, 1–9.

Zhijun, L., Rongchun, C., Feixiang, L., Yaohong, W., Ning, L., Shufang, Z., Mingliang, Z., & Hongfa, Z. (2019). Therapeutic effects of combined meloxicam and glucosamine sulfate treatment on patients with osteoarthritis, and its effect on serum CTX-I, CTX-II, COMP and MMP-3. Tropical Journal of Pharmaceutical Research, 18(7), 1553–1557.