EFEK ANTIMIKROBA EKSTRAK RIMPANG KUNYIT (CURCUMA DOMESTICA) TERHADAP ESCHERICHIA COLI SECARA IN VITRO
DOI:
https://doi.org/10.22219/sm.v10i2.4179Abstract
Pengaruh Pemberian Boraks Peroral Sub Akut Terhadap Terjadinya Atrofi Testis Tikus Putih Jantan (Rattus novergicus strain wistar). Latar Belakang: Penggunaan boraks banyak disalahgunakan pada makanan. Boraks merupakan salah satu bahan toksik bagi organ testis sehingga dapat menyebabkan atrofi testis melalui penghambatan spermatogenesis. Tujuan: Membuktikan pengaruh pemberian boraks peroral sub akut terhadap terjadinya atrofi testis tikus putih jantan (Rattus novergicus strain wistar) dengan mengukur diameter testis, berat testis, dan jumlah tubulus seminiferus perlapangpandang. Metode: Eksperimental, The Post Test Only Control Group Design. Sampel yang digunakan 24 ekor dibagi 4 kelompok. Kelompok 1 (kontrol negatif), kelompok 2,3,dan 4 masing-masing dengan dosis 400 mg/kgBB, 500 mg/kgBB, dan 600 mg/kgBB selama 28 hari. Dianalisis dengan oneway ANOVA, uji korelasi, dan uji regresi. Hasil penelitian dan diskusi: Terdapat perbedaan diameter testis dan jumlah tubulus seminiferus masing-masing dengan sig p=0,020 (p<0,05) dan sig p=0,00 (p<0,05), sedangkan pada berat testis tidak terdapat perbedaan dengan sig p=0,744 (p>0,05). Analisis korelasi diameter testis (p=0,001), (r=-0,613), jumlah tubulus (p=0,000), (r=0,828), kenaikan boraks menyebabkan penurunan diameter testis dan peningkatan jumlah tubulus. Analisis regresi R2 diameter testis= 0,376 dan R2 jumlah tubulus=0,685. Pada penelitian ini pengaruh boraks terlihat pada gambaran mikroskopis dibandingkan makroskopis, hal ini disebabkan oleh waktu paparan boraks yang kurang lama. Kesimpulan: Pemberian boraks peroral sub akut berpengaruh terhadap atrofi testis.Kata Kunci: Ekstrak rimpang temulawak, Staphylococcus aureus, KHM (Kadar Hambat Minimum), KBM (Kadar Bunuh Minimum).Downloads
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2017-03-21
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