CROSS TALK ANTARA SEL PUNCA KANKER DENGAN LINGKUNGAN MIKRO

Authors

  • Ruby Riana Asparini

DOI:

https://doi.org/10.22219/sm.v13i1.5431

Abstract

Pengetahuan tentang biologi tumor dan terapi tumor telah berkembang. Namun tumor tetap
merupakan penyakit umum yang mematikan di seluruh dunia. Sel punca kanker adalah bagian dari sel kanker
dengan kemampuan sel punca, yang dapat mendorong pertumbuhan tumor, kekambuhan dan tahan terhadap
banyak perawatan antikanker saat ini.Tumor padat dianggap sebagai “organ” yang terdiri dari sel kanker dan
stroma tumor. Lingkungan mikro tumor membentuk stroma tumor, yang menempati sebagian besar massa
tumor, termasuk matriks ekstraselular (ECM), sel induk mesenchymal (MSC), sel endotel, sel imun, dan, lebih
dari itu, jaringan sitokin dan faktor pertumbuhan. Lingkungan mikro atau nichesekitarsel punca kanker sebagian besar
mengatur nasib seluler mereka. Pengetahuan terbaru mengungkapkan bahwa lingkungan mikro mendukung pembaharuan
diri sel punca kanker dan sekaligus berfungsi sebagai penghalang fisik terhadap pemberian obat. Lingkungan mikro tumor
memainkan peran penting dalam setiap tahap perkembangan tumor.
Kata Kunci : Cross Talk, sell punca.

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Published

2018-03-28

Issue

Vol. 13 No. 1 (2017): JUNI 2017

Section

Article

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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.