CROSS TALK ANTARA SEL PUNCA KANKER DENGAN LINGKUNGAN MIKRO
DOI:
https://doi.org/10.22219/sm.v13i1.5431Abstract
Pengetahuan tentang biologi tumor dan terapi tumor telah berkembang. Namun tumor tetapmerupakan penyakit umum yang mematikan di seluruh dunia. Sel punca kanker adalah bagian dari sel kanker
dengan kemampuan sel punca, yang dapat mendorong pertumbuhan tumor, kekambuhan dan tahan terhadap
banyak perawatan antikanker saat ini.Tumor padat dianggap sebagai “organ” yang terdiri dari sel kanker dan
stroma tumor. Lingkungan mikro tumor membentuk stroma tumor, yang menempati sebagian besar massa
tumor, termasuk matriks ekstraselular (ECM), sel induk mesenchymal (MSC), sel endotel, sel imun, dan, lebih
dari itu, jaringan sitokin dan faktor pertumbuhan. Lingkungan mikro atau nichesekitarsel punca kanker sebagian besar
mengatur nasib seluler mereka. Pengetahuan terbaru mengungkapkan bahwa lingkungan mikro mendukung pembaharuan
diri sel punca kanker dan sekaligus berfungsi sebagai penghalang fisik terhadap pemberian obat. Lingkungan mikro tumor
memainkan peran penting dalam setiap tahap perkembangan tumor.
Kata Kunci : Cross Talk, sell punca.
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Published
2018-03-28
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