Cost-effectiveness analysis of cefazolin and clindamycin in postpartum patients at PKU Muhammadiyah Hospital Yogyakarta
DOI:
https://doi.org/10.22219/farmasains.v6i2.17289Keywords:
Effectiveness, Cost, Therapy, Antibiotics, PostpartumAbstract
Postpartum infections can occur after normal or cesarean delivery. Proper administration of antibiotics can reduce the risk of postpartum infection The occurrence of postpartum infections can increase the cost of childbirth. The purpose of this study is to find out the cost-effectiveness of antibiotic therapy at PKU Muhammadiyah Hospital Yogyakarta. This study was retrospective observational and was conducted during October to December 2020. The inclusion criteria in this study were postpartum patients who received cefazolin and clindamycin therapy and were over 20 years old, while the exclusion criteria in this study were patients who died, had incomplete data, and had complications of the disease. The effectiveness of antibiotic therapy was measured from the clinical outside of body temperature and length of hospitalization. Cost-effectiveness were assessed from ACER (Average Cost-effectiveness Ratio) and ICER (Incremental Cost-effectiveness Ratio). The results showed that the effectiveness of antibiotics based on the clinical outcome temperature and length of cefazolin of 81.3% and 2.7 days while in clindamycin by 18.8% and 1.8 days. The ACER (Average cost effectiveness ratio) based on the clinical output of body temperature in both groups was IDR 64,348 (cefazolin) and IDR 98,319 (clindamycin). ACER values based on long of stay (LOS) clinical discharge in both groups amounted to IDR 19,375 (cefazolin) and IDR 10,268 (clindamycin). The value of ICER (Incremental Cost- effectiveness Ratio) cefazolin against clindamycin based on the clinical output of temperature and length of hospitalization (LOS) respectively is IDR 54,129 and IDR 37,590 for each effectiveness achieved. The conclusion of this study is that the use of cefeazoline is more therapeutically effective than clindamycin with greater therapeutic costs.
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Admaja, W., Herowati, R., & Andayani, T. M. (2019). Analisis efektivitas biaya terapi penggunaan antibiotik profilaksis cefazoline dan amoxicillin pada kasus bedah sesar di RSUD Jombang tahun 2017. Jurnal Wiyata: Penelitian Sains dan Kesehatan, 6(1), 40-53.
Andayani, T. M. (2013). Farmakoekonomi Prinsip dan Metodologi. Yogyakarta, Indonesia: Bursa Ilmu.
Boushra, M., & Rahman, O. (2021). Postpartum Infection. Treasure Island, FL: StatPearls.
Center of Disease Control and Prevention. (2021, September 10). Preterm Birth. https://www.cdc.gov/reproductivehealth/maternalinfanthealth/pretermbirth.htm.
Cunningham, F., Leveno, K., Bloom, S., Hauth, J., Rouse, H., & Spong, C. (2013). Obstetri Williams Edisi 23. Jakarta, Indonesia: EGC.
Dudeck, M. A., Horan, T. C., Peterson, K. D., Allen-Bridson, K., Morrell, G., Anttila, A., ... & Edwards, J. R. (2013). National Healthcare Safety Network (NHSN) report, data summary for 2011, device-associated module. American journal of infection control, 41(4), 286-300.
Elattar, A., Selamat, E. M., Robson, A. A., & Loughney, A. D. (2008). Factors influencing maternal length of stay after giving birth in a UK hospital and the impact of those factors on bed occupancy. Journal of Obstetrics and Gynaecology, 28(1), 73-76.
Hardiyanti, R., Rosdiani, R., Kurniawati, E., & Sari, R. D. P. (2020). Studi Perbandingan Efektivitas Penggunaan Antibiotik Pada Pasien Sectio Caesarea Di RSUD Dr . H . Abdul Moeloek Provinsi Lampung Comparative Study of The Antibiotic Used Effectiveness In Sectio Caesarea. Archives Pharmacia, 2(1), 1-16.
Irwansyah, B. F. (2018). Gambaran Penggunaan Obat Pada Pasien Post Caesarea Di Rsia Puri Agung Magelang Periode Januari-Juni Tahun 2017. (Diploma Thesis). Universitas Muhammadiyah Magelang, Magelang, Indonesia.
Kementerian Kesehatan Republik Indonesia. (2013). Pedoman Penerapan Kajian Farmakoekonomi. Jakarta, Indonesia: Authors.
Prasanti, D. (2017). Peran Obat Tradisional Dalam Komunikasi Terapeutik Keluarga Di Era Digital. Jurnal Komunikasi Universitas Garut: Hasil Pemikiran dan Penelitian, 3(1), 17-27.
Prasetya, D. B. (2013). Efektifitas penggunaan antibiotik pada pasien seksio sesarea elektif di Rumah Sakit X Sidoarjo. Calyptra, 2(2), 1-10.
Salim, D. R., Sukarya, W. S., & Hikmawati, D. (2015). Hubungan Antara Usia, Paritas, dan Preeklampsia pada Ibu dengan Kelahiran Prematur di RSUD Al-Ihsan Bandung Tahun 2014. Prosiding Pendidikan Dokter, 1(2), 363-370.
Sharma, M., Sanneving, L., Mahadik, K., Santacatterina, M., Dhaneria, S., & Lundborg C. S. (2013). Antibiotic prescribing in women during and after delivery in a non-teaching, tertiary care hospital in Ujjain, India: a prospective cross-sectional study. Journal of Pharmaceutical Policy and Practice, 6(9). doi: https://doi.org/10.1186/2052-3211-6-9.
Venkatesh, K. K., Hughes, B. L., Grotegut, C. A., Strauss, R. A., Stamilio, D. M., Heine, R. P., & Dotters-Katz, S. K. (2020). Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery. American Journal of Obstetrics & Gynecology MFM, 2(1), 100074.
World Health Organization. (2015). WHO recommendations for prevention and treatment of maternal peripartum infections: evidence base (No. WHO/RHR/15.21). Geneva, Swiss: Authors.
Yanti, Y. E. (2015). Hubungan Pengetahuan Ibu Dan Dukungan Suami Pada Ibu Hamil Terhadap Keteraturan Kunjungan Antenatal Care (Anc) Di Puskesmas Wates Lampung Tengah Tahun 2015. Jurnal Kebidanan Malahayati, 1(2), 81-90.
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