Development microemulsion formulation combination of citronella and red ginger essential oil

Authors

  • Uswatun Chasanah Department of Pharmacy, Faculty of Health Science, University of Muhammadiyah Malang, Indonesia
  • Ellen Kusuma Wardhani Department of Pharmacy, Faculty of Health Science, University of Muhammadiyah Malang, Indonesia
  • Dian Ermawati Department of Pharmacy, Faculty of Health Science, University of Muhammadiyah Malang, Indonesia

DOI:

https://doi.org/10.22219/farmasains.v8i2.35039

Keywords:

Citronella oil, microemulsion, Red ginger oil, Tween 80, Transcutol, characteristic

Abstract

Acne vulgaris is a skin health problem. Citronella oil contains citronellal, geraniol, geranial, β-citronellol, and neral, which have antibacterial properties. Meanwhile, red ginger oil contains gingerol, which has anti-inflammatory properties. These two ingredients are suitable for treating acne vulgaris. The aim of this study are to develop microemulsion formulation combination of citronella and red ginger essential oil. In this experimental study, a microemulsion combination of citronella essential oil and red ginger essential oil was made using Tween 80 as a surfactant and Transcutol® as a co-surfactant, with variations of S-mix (surfactant:cosurfactant) of 3:3, 4:2, and 4.5:1.5 ratios. As an oil carrier, isopropyl myristate is used. The microemulsions are formulated using a titration method. The microemulsion was then tested for characteristics and stability. The results show that the most optimal microemulsion formula was obtained with an S-mix ratio of 4:2 with a globule size of 21.64 nm, a Polydispersion Index of 0.15, and a zeta potential of -3.82. Its pH and viscosity meet the required specifications and are stable.

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Published

2023-11-30 — Updated on 2023-11-30

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How to Cite

Chasanah, U., Wardhani, E. K., & Ermawati, D. (2023). Development microemulsion formulation combination of citronella and red ginger essential oil. Farmasains : Jurnal Farmasi Dan Ilmu Kesehatan, 8(2), 56–65. https://doi.org/10.22219/farmasains.v8i2.35039

Issue

Vol. 8 No. 2 (2023)

Section

Pharmaceutical Technology

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Copyright (c) 2023 Uswatun Chasanah, Ellen Kusuma Wardhani, Dian Ermawati

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