Profile protein autism analysis based bioinformatics as public dissemination materials in Malang about the potensial causes autism
DOI:
https://doi.org/10.22219/jpbi.v2i3.3876Keywords:
profil protein, autis, bioinformatik, sosialisasi, masyarakatAbstract
Kehidupan saat ini menawarkan berbagai kemudahan. Namun, seiring dengan hal tersebut ada banyak permasalahan yang memicu stress. Selain itu, terdapat banyak unsur kimia dan logam berat yang jika saling berinteraksi dapat menimbulkan berbagai macam penyakit mulai dari flu hingga kanker, termasuk autis. Penelitian ini bertujuan untuk menganalisis potensi profil protein dalam darah yang menyebabkan autis berdasarkan bioinformatik. Kemudian, disosialisasikan kepada masyarakat khususnya orang tua anak autis di Kota Malang sehingga dapat memberikan wawasan tentang autis. Penelitian ini juga dapat dikembangkan sebagai dasar penelitian laboratorium. Jenis penelitian ini adalah deskriptif kualitatif, menggunakan tiga database yaitu National Center for Biotechnology Information (NCBI), Uniprot, dan Protein Data Bank (PDB) serta menggunakan software Pymol. Hasil penelitian ini menunjukkan bahwa: 1) Protein dalam darah yang berpotensi menyebabkan autis berdasarkan artikel yaitu mTOR, Glutathione S Transferase P, Chemokine Monocyte Chemotactic Protein-1 (MCP-1), Interferon-∂-Inducible Protein-16 (IFI-16), dan serotonin; 2) Protein-protein tersebut setelah dianalisis dengan menggunakan tiga database (NCBI, Uniprot, dan PDB) menunjukkan bahwa protein Glutathione S Transferase P lebih berpotensi terhadap autis. Hal ini karena protein tersebut berfungsi untuk mencegah neurodegeneration; 3) Penelitian tentang penyebab autis sangat dibutuhkan oleh orang tua anak autis (masyarakat), sehingga dapat diminimalisir akses masuknya pemicu tersebut.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with JPBI (Jurnal Pendidikan Biologi Indonesia) agree to the following terms:
- For all articles published in JPBI, copyright is retained by the authors. Authors give permission to the publisher to announce the work with conditions. When the manuscript is accepted for publication, the authors agree to automatic transfer of the publishing right to the publisher.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.